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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50206584
Substrate
n/a
Meas. Tech.
ChEMBL_428724 (CHEMBL915240)
Ki
2028±n/a nM
Citation
 Prezzavento, O; Campisi, A; Ronsisvalle, S; Li Volti, G; Marrazzo, A; Bramanti, V; Cannavò, G; Vanella, L; Cagnotto, A; Mennini, T; Ientile, R; Ronsisvalle, G Novel sigma receptor ligands: synthesis and biological profile. J Med Chem 50:951-61 (2007) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50206584
Synonyms:
CHEMBL434385 | methyl (1R,2S/1S,2R)-1-(4-methoxyphenyl)-2-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]cyclopropanecarboxylate
Type:
Small organic molecule
Emp. Form.:
C21H26N4O3
Mol. Mass.:
382.4561
SMILES:
COC(=O)C1(CC1CN1CCN(CC1)c1ncccn1)c1ccc(OC)cc1
Structure:
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