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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50207902
Substrate
n/a
Meas. Tech.
ChEMBL_438518 (CHEMBL886492)
Ki
400±n/a nM
Citation
 Rowbottom, MW; Vickers, TD; Tamiya, J; Zhang, M; Dyck, B; Grey, J; Schwarz, D; Heise, CE; Hedrick, M; Wen, J; Tang, H; Wang, H; Fisher, A; Aparicio, A; Saunders, J; Goodfellow, VS Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Bioorg Med Chem Lett 17:2171-8 (2007) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50207902
Synonyms:
1-(2-fluoro-benzyl)-8-(4-imidazol-1-yl-benzyl)-3-phenethyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione | CHEMBL427262
Type:
Small organic molecule
Emp. Form.:
C32H32FN5O2
Mol. Mass.:
537.6272
SMILES:
Fc1ccccc1CN1C(=O)N(CCc2ccccc2)C(=O)C11CCN(Cc2ccc(cc2)-n2ccnc2)CC1
Structure:
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