Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50209897
Substrate
n/a
Meas. Tech.
ChEMBL_443802 (CHEMBL892965)
IC50
850±n/a nM
Citation
Ishihara, T; Seki, N; Hirayama, F; Orita, M; Koshio, H; Taniuchi, Y; Sakai-Moritani, Y; Iwatsuki, Y; Kaku, S; Kawasaki, T; Matsumoto, Y; Tsukamoto, S Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors. Bioorg Med Chem 15:4175-92 (2007) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50209897
Synonyms:
7-{[(1-benzenesulfonyl-piperidin-4-yl)-methanesulfonyl-amino]-methyl}-naphthalene-2-carboxamidine | CHEMBL241911
Type:
Small organic molecule
Emp. Form.:
C24H28N4O4S2
Mol. Mass.:
500.634
SMILES:
CS(=O)(=O)N(Cc1ccc2ccc(cc2c1)C(N)=N)C1CCN(CC1)S(=O)(=O)c1ccccc1