Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50211563
Substrate
n/a
Meas. Tech.
ChEMBL_438714 (CHEMBL889048)
Ki
0.24±n/a nM
Citation
Dönnecke, D; Schweinitz, A; Stürzebecher, A; Steinmetzer, P; Schuster, M; Stürzebecher, U; Nicklisch, S; Stürzebecher, J; Steinmetzer, T From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3. Bioorg Med Chem Lett 17:3322-9 (2007) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50211563
Synonyms:
(S)-4-(2-aminomethyl-5-chloro-benzylcarbamoyl)-4-{methoxy-[(R)-4-(1-oxy-pyridin-2-yl)-2-phenylmethanesulfonylamino-butyryl]-amino}-butyric acid | CHEMBL397895
Type:
Small organic molecule
Emp. Form.:
C30H36ClN5O8S
Mol. Mass.:
662.154
SMILES:
CON([C@@H](CCC(O)=O)C(=O)NCc1cc(Cl)ccc1CN)C(=O)[C@@H](CCc1cccc[n+]1[O-])NS(=O)(=O)Cc1ccccc1