Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50211683
Substrate
n/a
Meas. Tech.
ChEMBL_436390 (CHEMBL904698)
Ki
>1000±n/a nM
Citation
 Vidal, B; Nueda, A; Esteve, C; Domenech, T; Benito, S; Reinoso, RF; Pont, M; Calbet, M; López, R; Cadavid, MI; Loza, MI; Cárdenas, A; Godessart, N; Beleta, J; Warrellow, G; Ryder, H Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist. J Med Chem 50:2732-6 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50211683
Synonyms:
1-(cyclopropylmethyl)-5-{[4'-(2-furyl)-4,5'-bipyrimidin-2'-yl]amino}pyridin-2(1H)-one | CHEMBL225982
Type:
Small organic molecule
Emp. Form.:
C21H18N6O2
Mol. Mass.:
386.4066
SMILES:
O=c1ccc(Nc2ncc(-c3ccncn3)c(n2)-c2ccco2)cn1CC1CC1
Structure:
Search PDB for entries with ligand similarity: