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Target
B1 bradykinin receptor
Ligand
BDBM50212098
Substrate
n/a
Meas. Tech.
ChEMBL_447237 (CHEMBL897541)
Ki
1.39±n/a nM
Citation
 Kuduk, SD; DiPardo, RM; Chang, RK; Di Marco, CN; Murphy, KL; Ransom, RW; Reiss, DR; Tang, C; Prueksaritanont, T; Pettibone, DJ; Bock, MG Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series. Bioorg Med Chem Lett 17:3608-12 (2007) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50212098
Synonyms:
1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid {(R)-1-[5'-chloro-3-fluoro-2'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-yl]-ethyl}-amide | CHEMBL233351
Type:
Small organic molecule
Emp. Form.:
C23H19ClF4N4O3
Mol. Mass.:
510.869
SMILES:
C[C@@H](NC(=O)C1(CC1)NC(=O)C(F)(F)F)c1ccc(cc1F)-c1cc(Cl)ccc1-c1noc(C)n1
Structure:
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