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Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50176175
Substrate
n/a
Meas. Tech.
ChEMBL_459062 (CHEMBL925154)
IC50
107±n/a nM
Citation
 Patel, MR; Talele, TT 3D-QSAR studies on malonyl coenzyme A decarboxylase inhibitors. Bioorg Med Chem 15:4470-81 (2007) [PubMed]  Article 
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
  
Inhibitor
Name:
BDBM50176175
Synonyms:
5-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)methoxy)pentanenitrile | CHEMBL440043
Type:
Small organic molecule
Emp. Form.:
C21H23F6N3O2
Mol. Mass.:
463.4166
SMILES:
CC(C)c1ncc(COCCCCC#N)n1-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: