Target
Tyrosine-protein kinase ITK/TSK
Ligand
BDBM50212784
Substrate
n/a
Meas. Tech.
ChEMBL_447339 (CHEMBL896373)
IC50
>20000±n/a nM
Citation
 Snow, RJAbeywardane, ACampbell, SLord, JKashem, MAKhine, HHKing, JKowalski, JAPullen, SSRoma, TRoth, GPSarko, CRWilson, NSWinters, MPWolak, JPCywin, CL Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors. Bioorg Med Chem Lett 17:3660-5 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ITK/TSK
Synonyms:
EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:
Protein
Mol. Mass.:
71839.20
Organism:
Homo sapiens (Human)
Description:
Q08881
Residue:
620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
  
Inhibitor
Name:
BDBM50212784
Synonyms:
1-(3-amino-3-oxopropyl)-N-cyclohexyl-2-(thiophene-4-carboxamido)-1H-benzo[d]imidazole-5-carboxamide | CHEMBL391883
Type:
Small organic molecule
Emp. Form.:
C22H25N5O3S
Mol. Mass.:
439.531
SMILES:
NC(=O)CCn1c(NC(=O)c2ccsc2)nc2cc(ccc12)C(=O)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: