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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50214210
Substrate
n/a
Meas. Tech.
ChEMBL_436999 (CHEMBL886015)
EC50
19±n/a nM
Citation
 Kasuga, J; Nakagome, I; Aoyama, A; Sako, K; Ishizawa, M; Ogura, M; Makishima, M; Hirono, S; Hashimoto, Y; Miyachi, H Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists. Bioorg Med Chem 15:5177-90 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50214210
Synonyms:
3-(4-methoxy-3-((4-(trifluoromethyl)benzamido)methyl)phenyl)-2-methylpropanoic acid | 3-{4-methoxy-3-[(4-trifluoromethylbenzoylamino)-methyl]phenyl}-2-methylpropanoic acid | CHEMBL229785
Type:
Small organic molecule
Emp. Form.:
C20H20F3NO4
Mol. Mass.:
395.3723
SMILES:
COc1ccc(CC(C)C(O)=O)cc1CNC(=O)c1ccc(cc1)C(F)(F)F |w:7.7|
Structure:
Search PDB for entries with ligand similarity: