Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50214210
Substrate
n/a
Meas. Tech.
ChEMBL_437000 (CHEMBL886016)
EC50
210±n/a nM
Citation
 Kasuga, J; Nakagome, I; Aoyama, A; Sako, K; Ishizawa, M; Ogura, M; Makishima, M; Hirono, S; Hashimoto, Y; Miyachi, H Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists. Bioorg Med Chem 15:5177-90 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50214210
Synonyms:
3-(4-methoxy-3-((4-(trifluoromethyl)benzamido)methyl)phenyl)-2-methylpropanoic acid | 3-{4-methoxy-3-[(4-trifluoromethylbenzoylamino)-methyl]phenyl}-2-methylpropanoic acid | CHEMBL229785
Type:
Small organic molecule
Emp. Form.:
C20H20F3NO4
Mol. Mass.:
395.3723
SMILES:
COc1ccc(CC(C)C(O)=O)cc1CNC(=O)c1ccc(cc1)C(F)(F)F |w:7.7|
Structure:
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