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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50215212
Substrate
n/a
Meas. Tech.
ChEMBL_448200 (CHEMBL898460)
Ki
1710±n/a nM
Citation
 Lanier, MC; Feher, M; Ashweek, NJ; Loweth, CJ; Rueter, JK; Slee, DH; Williams, JP; Zhu, YF; Sullivan, SK; Brown, MS Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists. Bioorg Med Chem 15:5590-603 (2007) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50215212
Synonyms:
6-(2,4-dimethylbenzyl)-1-(2,6-difluorobenzyl)-3-((1-methylpiperidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione | CHEMBL392087
Type:
Small organic molecule
Emp. Form.:
C30H36F2N4O2
Mol. Mass.:
522.6292
SMILES:
CN1CCCCC1Cn1c(=O)c2CN(Cc3ccc(C)cc3C)CCc2n(Cc2c(F)cccc2F)c1=O |w:6.7|
Structure:
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