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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50215626
Substrate
n/a
Meas. Tech.
ChEMBL_437192 (CHEMBL906590)
Ki
21±n/a nM
Citation
 Su, J; McKittrick, BA; Tang, H; Burnett, DA; Clader, JW; Greenlee, WJ; Hawes, BE; O'Neill, K; Spar, B; Weig, B; Kowalski, T; Sorota, S; Li, C; Liu, T SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG. Bioorg Med Chem 15:5369-85 (2007) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50215626
Synonyms:
3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-(((S)-3-hydroxypyrrolidin-1-yl)methyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea | CHEMBL229229
Type:
Small organic molecule
Emp. Form.:
C33H46ClFN4O2
Mol. Mass.:
585.195
SMILES:
CC(C)N(CCN([C@@H]1CC[C@@]2(CC2C1)c1cccc(CN2CC[C@H](O)C2)c1)C(=O)Nc1ccc(F)c(Cl)c1)C(C)C |w:12.11|
Structure:
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