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Target
Histone deacetylase 1
Ligand
BDBM50216020
Substrate
n/a
Meas. Tech.
ChEMBL_456584 (CHEMBL923961)
IC50
630±n/a nM
Citation
 Witter, DJ; Belvedere, S; Chen, L; Secrist, JP; Mosley, RT; Miller, TA Benzo[b]thiophene-based histone deacetylase inhibitors. Bioorg Med Chem Lett 17:4562-7 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50216020
Synonyms:
CHEMBL246759 | methyl 2-(hydroxycarbamoyl)benzo[b]thiophene-6-carboxylate
Type:
Small organic molecule
Emp. Form.:
C11H9NO4S
Mol. Mass.:
251.258
SMILES:
COC(=O)c1ccc2cc(sc2c1)C(=O)NO
Structure:
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