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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50217702
Substrate
n/a
Meas. Tech.
ChEMBL_448689 (CHEMBL896689)
Ki
1800±n/a nM
Citation
 Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem 15:5787-810 (2007) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50217702
Synonyms:
1-(3-aminocyclohexyl)-3-((1r,4r)-4-(N-benzyl-4-(1H-indol-3-yl)butanamido)cyclohexyl)urea | CHEMBL238158
Type:
Small organic molecule
Emp. Form.:
C32H43N5O2
Mol. Mass.:
529.7161
SMILES:
NC1CCCC(C1)NC(=O)N[C@H]1CC[C@@H](CC1)N(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12 |wU:11.11,wD:14.18,(4.98,-7.56,;4.96,-9.1,;6.29,-9.88,;6.27,-11.42,;4.93,-12.17,;3.61,-11.39,;3.62,-9.85,;2.27,-12.15,;.94,-11.37,;.95,-9.83,;-.4,-12.13,;-.41,-13.67,;.92,-14.46,;.91,-15.99,;-.42,-16.76,;-1.76,-15.98,;-1.75,-14.44,;-.43,-18.3,;-1.76,-19.06,;-3.08,-18.28,;-3.06,-16.75,;-4.38,-15.98,;-5.72,-16.74,;-5.72,-18.28,;-4.4,-19.04,;.9,-19.07,;.9,-20.61,;2.24,-18.3,;3.57,-19.08,;4.91,-18.31,;6.24,-19.09,;7.5,-18.18,;8.75,-19.1,;8.25,-20.57,;9.02,-21.9,;8.23,-23.23,;6.69,-23.22,;5.94,-21.88,;6.71,-20.56,)|
Structure:
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