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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50217717
Substrate
n/a
Meas. Tech.
ChEMBL_448689 (CHEMBL896689)
Ki
2100±n/a nM
Citation
 Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem 15:5787-810 (2007) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50217717
Synonyms:
CHEMBL393994 | methyl 4-((N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamido)methyl)benzoate
Type:
Small organic molecule
Emp. Form.:
C34H45N3O3
Mol. Mass.:
543.7394
SMILES:
COC(=O)c1ccc(CN(C2CCC(CC3CCC(N)CC3)CC2)C(=O)CCCc2c[nH]c3ccccc23)cc1 |(25.03,-34.28,;26.37,-35.05,;27.7,-34.28,;27.7,-32.74,;29.04,-35.05,;30.37,-34.28,;31.7,-35.05,;31.7,-36.59,;33.03,-37.36,;34.36,-36.59,;34.36,-35.03,;35.71,-34.26,;35.72,-32.71,;34.37,-31.93,;34.38,-30.39,;35.71,-29.62,;37.04,-30.41,;38.38,-29.65,;38.39,-28.11,;39.73,-27.35,;37.06,-27.33,;35.72,-28.09,;33.02,-32.7,;33.01,-34.26,;35.71,-37.37,;35.71,-38.92,;37.05,-36.59,;38.38,-37.36,;39.72,-36.58,;41.05,-37.35,;41.63,-35.93,;43.17,-36.03,;43.54,-37.53,;44.89,-38.25,;44.94,-39.78,;43.63,-40.6,;42.28,-39.87,;42.23,-38.33,;30.37,-37.36,;29.04,-36.59,)|
Structure:
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