Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50218098
Substrate
n/a
Meas. Tech.
ChEMBL_457011 (CHEMBL923354)
Ki
4800±n/a nM
Citation
 Tran, JA; Chen, CW; Jiang, W; Tucci, FC; Fleck, BA; Marinkovic, D; Arellano, M; Chen, C Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett 17:5165-70 (2007) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50218098
Synonyms:
2-(4-((3R,4S)-3-(4-chlorophenyl)-1-isopropylpyrrolidine-4-carbonyl)piperazin-1-yl)benzonitrile | CHEMBL398854
Type:
Small organic molecule
Emp. Form.:
C25H29ClN4O
Mol. Mass.:
436.977
SMILES:
CC(C)N1C[C@H]([C@@H](C1)c1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1C#N
Structure:
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