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Target
D(3) dopamine receptor
Ligand
BDBM50219942
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
2±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219942
Synonyms:
CHEMBL240051 | N-((1r,4r)-4-(2-(4-(2,5-dichlorophenylamino)piperidin-1-yl)ethyl)cyclohexyl)-4-fluorobenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C25H32Cl2FN3O2S
Mol. Mass.:
528.51
SMILES:
Fc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)Nc2cc(Cl)ccc2Cl)CC1 |wU:11.11,wD:14.15,(-11.09,3.77,;-9.76,3,;-8.41,3.77,;-7.08,3,;-7.08,1.45,;-8.41,.68,;-9.75,1.45,;-5.74,.68,;-6.5,-.65,;-4.99,2.02,;-4.38,-.08,;-3.04,.72,;-3.04,2.27,;-1.71,3.03,;-.37,2.27,;.96,3.04,;2.29,2.27,;3.63,3.04,;4.96,2.26,;6.29,3.02,;6.3,4.56,;4.96,5.34,;3.62,4.57,;7.63,5.33,;8.95,4.55,;10.28,5.32,;11.6,4.55,;12.94,5.32,;11.6,3.01,;10.27,2.24,;8.95,3.02,;7.6,2.26,;-.37,.72,;-1.71,-.05,)|
Structure:
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