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Target
D(2) dopamine receptor
Ligand
BDBM50213533
Substrate
n/a
Meas. Tech.
ChEMBL_450225 (CHEMBL900500)
Ki
88±n/a nM
Citation
 Chiu, G; Li, S; Cai, H; Connolly, PJ; Peng, S; Stauber, K; Pulito, V; Liu, J; Middleton, SA Aminocyclohexylsulfonamides: discovery of metabolically stable alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Bioorg Med Chem Lett 17:6123-8 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50213533
Synonyms:
CHEMBL228607 | N-((1r,4r)-4-(4-(2-(2,2-difluoroethoxy)phenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C27H36F2N2O5S
Mol. Mass.:
538.647
SMILES:
COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)F |wU:17.21,wD:14.14,(32.79,-36.92,;31.25,-36.91,;30.47,-38.24,;28.91,-38.24,;28.14,-39.59,;28.9,-40.91,;30.46,-40.91,;31.23,-39.59,;32.77,-39.6,;33.53,-40.94,;28.13,-42.25,;26.81,-41.49,;29.49,-43.03,;27.38,-43.56,;25.8,-43.56,;25.04,-42.25,;23.51,-42.21,;22.75,-43.53,;23.52,-44.88,;25.04,-44.88,;21.18,-43.53,;20.41,-44.86,;18.88,-44.86,;18.11,-43.51,;18.88,-42.18,;20.41,-42.21,;16.55,-43.51,;15.78,-44.85,;14.24,-44.85,;13.47,-43.5,;14.25,-42.18,;15.78,-42.18,;16.55,-40.83,;15.78,-39.5,;16.55,-38.16,;15.78,-36.83,;18.09,-38.16,)|
Structure:
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