Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM32686
Substrate
n/a
Meas. Tech.
ChEMBL_452413 (CHEMBL902649)
Kd
>1000000±n/a nM
Citation
 Stebbins, JLZhang, ZChen, JWu, BEmdadi, AWilliams, MECashman, JPellecchia, M Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. J Med Chem 50:6607-17 (2007) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM32686
Synonyms:
4-(2-Morpholin-4-yl-2-oxo-ethoxy)-N-p-tolyl-benzenesulfonamide | 4-(2-keto-2-morpholino-ethoxy)-N-(p-tolyl)benzenesulfonamide | CHEMBL235929 | MLS000124061 | N-(4-methylphenyl)-4-(2-morpholin-4-yl-2-oxidanylidene-ethoxy)benzenesulfonamide | N-(4-methylphenyl)-4-(2-morpholin-4-yl-2-oxoethoxy)benzenesulfonamide | N-(4-methylphenyl)-4-[2-(4-morpholinyl)-2-oxoethoxy]benzenesulfonamide | SMR000124525 | cid_1092897
Type:
Small organic molecule
Emp. Form.:
C19H22N2O5S
Mol. Mass.:
390.453
SMILES:
Cc1ccc(NS(=O)(=O)c2ccc(OCC(=O)N3CCOCC3)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: