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Target
Translocator protein
Ligand
BDBM50229596
Substrate
n/a
Meas. Tech.
ChEMBL_460138 (CHEMBL924980)
Ki
0.73±n/a nM
Citation
 Briard, E; Zoghbi, SS; Imaizumi, M; Gourley, JP; Shetty, HU; Hong, J; Cropley, V; Fujita, M; Innis, RB; Pike, VW Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem 51:17-30 (2008) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50229596
Synonyms:
1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl]isoquinoline-3-carboxamide | CHEMBL251953 | PK-11195
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O
Mol. Mass.:
352.857
SMILES:
CC[C@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Structure:
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