Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50232253
Substrate
n/a
Meas. Tech.
ChEMBL_460924 (CHEMBL943951)
EC50
16700±n/a nM
Citation
 Tikhonova, IG; Sum, CS; Neumann, S; Engel, S; Raaka, BM; Costanzi, S; Gershengorn, MC Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening. J Med Chem 51:625-33 (2008) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50232253
Synonyms:
CHEMBL252526 | methyl 2-(5-(benzylthio)-1,3,4-thiadiazol-2-ylthio)acetate
Type:
Small organic molecule
Emp. Form.:
C12H12N2O2S3
Mol. Mass.:
312.431
SMILES:
COC(=O)CSc1nnc(SCc2ccccc2)s1
Structure:
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