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Target
Cyclin-dependent kinase 2
Ligand
BDBM8384
Substrate
n/a
Meas. Tech.
ChEMBL_510894 (CHEMBL997786)
IC50
497±n/a nM
Citation
 Patel, DS; Bharatam, PV Selectivity criterion for pyrazolo[3,4-b]pyrid[az]ine derivatives as GSK-3 inhibitors: CoMFA and molecular docking studies. Eur J Med Chem 43:949-57 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM8384
Synonyms:
CHEMBL260929 | N-[6-(1H-pyrrol-2-yl)-1H-indazol-3-yl]cyclopropanecarboxamide | indazole analogue 26
Type:
Small organic molecule
Emp. Form.:
C15H14N4O
Mol. Mass.:
266.2979
SMILES:
O=C(Nc1n[nH]c2cc(ccc12)-c1ccc[nH]1)C1CC1
Structure:
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