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Target
TGF-beta receptor type-1
Ligand
BDBM50271723
Substrate
n/a
Meas. Tech.
ChEMBL_552454 (CHEMBL1002714)
IC50
16000±n/a nM
Citation
 Shimizu, T; Kimura, K; Sakai, T; Kawakami, K; Miyazaki, T; Nakouji, M; Ogawa, A; Ohuchi, H; Shimizu, K Synthesis and evaluation of [2-(4-quinolyloxy)phenyl]methanone derivatives: novel selective inhibitors of transforming growth factor-beta kinase. J Med Chem 51:3326-9 (2008) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50271723
Synonyms:
CHEMBL482728 | {2-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}(phenyl)methanone
Type:
Small organic molecule
Emp. Form.:
C24H19NO4
Mol. Mass.:
385.412
SMILES:
COc1cc2nccc(Oc3ccccc3C(=O)c3ccccc3)c2cc1OC
Structure:
Search PDB for entries with ligand similarity: