Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM50271200
Substrate
n/a
Meas. Tech.
ChEMBL_556877 (CHEMBL964737)
IC50
>50000±n/a nM
Citation
 Tsou, HR; Otteng, M; Tran, T; Floyd, MB; Reich, M; Birnberg, G; Kutterer, K; Ayral-Kaloustian, S; Ravi, M; Nilakantan, R; Grillo, M; McGinnis, JP; Rabindran, SK 4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4 (CDK4). J Med Chem 51:3507-25 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50271200
Synonyms:
(4Z)-4-({[4-Piperidin-1-ylmethyl]phenyl}amino)methylene)-6-pyridin-3-ylisoquinoline-1,3(2H,4H)-dione | CHEMBL486711
Type:
Small organic molecule
Emp. Form.:
C26H25N3O2S
Mol. Mass.:
443.561
SMILES:
O=C1NC(=O)c2ccc(cc2C1=CNc1ccc(CN2CCCCC2)cc1)-c1ccsc1 |w:12.14|
Structure:
Search PDB for entries with ligand similarity: