Reaction Details Report a problem with these data
Target
Leukotriene A-4 hydrolase
Ligand
BDBM50251520
Substrate
n/a
Meas. Tech.
ChEMBL_488137 (CHEMBL987428)
IC50
1000±n/a nM
Citation
 Ye, B; Bauman, J; Chen, M; Davey, D; Khim, SK; King, B; Kirkland, T; Kochanny, M; Liang, A; Lentz, D; May, K; Mendoza, L; Phillips, G; Selchau, V; Schlyer, S; Tseng, JL; Wei, RG; Ye, H; Parkinson, J; Guilford, WJ Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett 18:3891-4 (2008) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50251520
Synonyms:
4-((4-(2-oxo-2-(4-phenoxyphenylamino)ethyl)piperazin-1-yl)methyl)benzoic acid | CHEMBL519264
Type:
Small organic molecule
Emp. Form.:
C26H27N3O4
Mol. Mass.:
445.5103
SMILES:
OC(=O)c1ccc(CN2CCN(CC(=O)Nc3ccc(Oc4ccccc4)cc3)CC2)cc1
Structure:
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