Reaction Details Report a problem with these data
Target
Leukotriene A-4 hydrolase
Ligand
BDBM50251706
Substrate
n/a
Meas. Tech.
ChEMBL_488464 (CHEMBL990997)
IC50
7±n/a nM
Citation
 Khim, SK; Bauman, J; Evans, J; Freeman, B; King, B; Kirkland, T; Kochanny, M; Lentz, D; Liang, A; Mendoza, L; Phillips, G; Tseng, JL; Wei, RG; Ye, H; Yu, L; Parkinson, J; Guilford, WJ Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett 18:3895-8 (2008) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50251706
Synonyms:
4-((3-(4-(4-(oxazol-2-yl)phenoxy)phenylamino)pyrrolidin-1-yl)methyl)benzoic acid | CHEMBL479956
Type:
Small organic molecule
Emp. Form.:
C27H25N3O4
Mol. Mass.:
455.5051
SMILES:
OC(=O)c1ccc(CN2CCC(C2)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: