Target
Group IIE secretory phospholipase A2
Ligand
BDBM50263001
Substrate
n/a
Meas. Tech.
ChEMBL_489274 (CHEMBL990830)
IC50
840±n/a nM
Citation
 Oslund, RCCermak, NGelb, MH Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem 51:4708-14 (2008) [PubMed]  Article 
Target
Name:
Group IIE secretory phospholipase A2
Synonyms:
GIIE sPLA2 | PA2GE_HUMAN | PLA2G2E | Phosphatidylcholine 2-acylhydrolase GIIE | sPLA(2)-IIE
Type:
PROTEIN
Mol. Mass.:
15997.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_489274
Residue:
142
Sequence:
MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC
  
Inhibitor
Name:
BDBM50263001
Synonyms:
2-(1-benzyl-2-isobutyl-1H-6,7-benzoindol-4-yloxy)-N-(phenylsulfonyl)acetamide | CHEMBL506485
Type:
Small organic molecule
Emp. Form.:
C33H31N3O6S
Mol. Mass.:
597.681
SMILES:
CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: