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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50244683
Substrate
n/a
Meas. Tech.
ChEMBL_512176 (CHEMBL968035)
EC50
24±n/a nM
Citation
 Semple, G; Fioravanti, B; Pereira, G; Calderon, I; Uy, J; Choi, K; Xiong, Y; Ren, A; Morgan, M; Dave, V; Thomsen, W; Unett, DJ; Xing, C; Bossie, S; Carroll, C; Chu, ZL; Grottick, AJ; Hauser, EK; Leonard, J; Jones, RM Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem 51:5172-5 (2008) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50244683
Synonyms:
(4-Methanesulfonyl-phenyl)-(5-nitro-6-{4-[3-(3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-pyrimidin-4-yl)-amine | CHEMBL500750
Type:
Small organic molecule
Emp. Form.:
C25H22F3N7O5S
Mol. Mass.:
589.546
SMILES:
CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)-c3cccc(c3)C(F)(F)F)c2[N+]([O-])=O)cc1
Structure:
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