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Target
Cathepsin K
Ligand
BDBM50223934
Substrate
n/a
Meas. Tech.
ChEMBL_513250 (CHEMBL980886)
IC50
27±n/a nM
Citation
 Teno, N; Masuya, K; Ehara, T; Kosaka, T; Miyake, T; Irie, O; Hitomi, Y; Matsuura, N; Umemura, I; Iwasaki, G; Fukaya, H; Toriyama, K; Uchiyama, N; Nonomura, K; Sugiyama, I; Kometani, M Effect of cathepsin K inhibitors on bone resorption. J Med Chem 51:5459-62 (2008) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_RAT | Ctsk
Type:
PROTEIN
Mol. Mass.:
36798.82
Organism:
Rattus norvegicus
Description:
ChEMBL_633322
Residue:
329
Sequence:
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM
  
Inhibitor
Name:
BDBM50223934
Synonyms:
7-(2,2-Dimethyl-propyl)-6-(2,4-dioxo-8-propyl-1,3,8-triaza-spiro[4.5]dec-3-ylmethyl)-7Hpyrrolo[2,3-d]pyrimidine-2-carbonitrile | 7-(2,2-dimethyl-propyl)-6-(2,4-dioxo-8-propyl-1,3,8-triaza-spiro[4.5]dec-3-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL400491
Type:
Small organic molecule
Emp. Form.:
C23H31N7O2
Mol. Mass.:
437.5379
SMILES:
CCCN1CCC2(CC1)NC(=O)N(Cc1cc3cnc(nc3n1CC(C)(C)C)C#N)C2=O
Structure:
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