Reaction Details Report a problem with these data
Target
Calcitonin gene-related peptide type 1 receptor
Ligand
BDBM50246085
Substrate
n/a
Meas. Tech.
ChEMBL_558102 (CHEMBL956592)
Ki
41±n/a nM
Citation
Theberge, CR; Bednar, RA; Bell, IM; Corcoran, HA; Fay, JF; Hershey, JC; Johnston, VK; Kane, SA; Mosser, S; Salvatore, CA; Williams, TM; Zartman, CB; Zhang, XF; Graham, SL; Vacca, JP Potent benzimidazolone-based CGRP receptor antagonists. Bioorg Med Chem Lett 18:6122-5 (2008) [PubMed] Article
More Info.:
Target
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52980.45
Organism:
Homo sapiens (Human)
Description:
Q16602
Residue:
461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
Inhibitor
Name:
BDBM50246085
Synonyms:
(R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(4-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide | CHEMBL471359
Type:
Small organic molecule
Emp. Form.:
C22H21N5O4
Mol. Mass.:
419.4332
SMILES:
CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cccc(C)c4[nH]c3=O)cc2C1 |r|