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Target
Peptidylglycine alpha-amidating monooxygenase
Ligand
BDBM50273962
Substrate
n/a
Meas. Tech.
ChEMBL_536304 (CHEMBL990738)
Ki
3800000±n/a nM
Citation
 Merkler, DJ; Asser, AS; Baumgart, LE; Carballo, N; Carpenter, SE; Chew, GH; Cosner, CC; Dusi, J; Galloway, LC; Lowe, AB; Lowe, EW; King, L; Kendig, RD; Kline, PC; Malka, R; Merkler, KA; McIntyre, NR; Romero, M; Wilcox, BJ; Owen, TC Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM). Bioorg Med Chem 16:10061-74 (2008) [PubMed]  Article 
Target
Name:
Peptidylglycine alpha-amidating monooxygenase
Synonyms:
AMD_RAT | Pam | Peptidyl-glycine alpha-amidating monooxygenase
Type:
PROTEIN
Mol. Mass.:
108665.78
Organism:
Rattus norvegicus
Description:
ChEMBL_536304
Residue:
976
Sequence:
MAGRARSGLLLLLLGLLALQSSCLAFRSPLSVFKRFKETTRSFSNECLGTIGPVTPLDASDFALDIRMPGVTPKESDTYFCMSMRLPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHKDCSGVSVHLTRVPQPLIAGMYLMMSVDTVIPPGEKVVNADISCQYKMYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQNPQLPQAFYPVEHPVDVTFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKYALSFMTCTKNVAPDMFRTIPAEANIPIPVKPDMVMMHGHHKEAENKEKSALMQQPKQGEEEVLEQGDFYSLLSKLLGEREDVHVHKYNPTEKTESGSDLVAEIANVVQKKDLGRSDAREGAEHEEWGNAILVRDRIHRFHQLESTLRPAESRAFSFQQPGEGPWEPEPSGDFHVEEELDWPGVYLLPGQVSGVALDSKNNLVIFHRGDHVWDGNSFDSKFVYQQRGLGPIEEDTILVIDPNNAEILQSSGKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLDPHSKEGPLLILGRSMQPGSDQNHFCQPTDVAVEPSTGAVFVSDGYCNSRIVQFSPSGKFVTQWGEESSGSSPRPGQFSVPHSLALVPHLDQLCVADRENGRIQCFKTDTKEFVREIKHASFGRNVFAISYIPGFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKMEHRSVKKAGIEVQEIKEAEAVVEPKVENKPTSSELQKMQEKQKLSTEPGSGVSVVLITTLLVIPVLVLLAIVMFIRWKKSRAFGDHDRKLESSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRVSTEGSDQEKDEDDGTESEEEYSAPLPKPAPSS
  
Inhibitor
Name:
BDBM50273962
Synonyms:
CHEMBL445286 | Phenylthioacetylglycine
Type:
Small organic molecule
Emp. Form.:
C10H11NO2S
Mol. Mass.:
209.265
SMILES:
OC(=O)CNC(=S)Cc1ccccc1
Structure:
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