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Target
Wee1-like protein kinase
Ligand
BDBM50192373
Substrate
n/a
Meas. Tech.
ChEMBL_522127 (CHEMBL1006579)
IC50
130±n/a nM
Citation
 Wichapong, K; Lindner, M; Pianwanit, S; Kokpol, S; Sippl, W Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem 44:1383-95 (2009) [PubMed]  Article 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM50192373
Synonyms:
9-hydroxy-5-methyl-4-phenylpyrrolo[3,4-c]-carbazole-1,3(2H,6H)-dione | 9-hydroxy-5-methyl-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL214341
Type:
Small organic molecule
Emp. Form.:
C21H14N2O3
Mol. Mass.:
342.3475
SMILES:
Cc1c(c2C(=O)NC(=O)c2c2c1[nH]c1ccc(O)cc21)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: