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Target
Gag polyprotein
Ligand
BDBM50273881
Substrate
n/a
Meas. Tech.
ChEMBL_536774 (CHEMBL984568)
IC50
12000±n/a nM
Citation
 LaFrate, AL; Gunther, JR; Carlson, KE; Katzenellenbogen, JA Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor. Bioorg Med Chem 16:10075-84 (2008) [PubMed]  Article 
Target
Name:
Gag polyprotein
Synonyms:
GAG_AVIER | gag
Type:
PROTEIN
Mol. Mass.:
61664.68
Organism:
Avian erythroblastosis virus (strain ES4)
Description:
ChEMBL_536774
Residue:
555
Sequence:
REEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATERRIDKGEEMGETTVQRDAKMAPEKMATPKTVGTSCYQCGTATGCNCVTASAPPPPYVGSGLYPSLAGAGEQGQGGDTPRGAEQPRAEPGHAGQAPGPALTDWARIREELASTGPPVVAMPVVIKTEGPAWTPLEPEDTRWLDGKHKRKSSQCLVKSSMSGYIPSCLDKDEQCVVCGDKATGYHYRCITCEGCKSFFRRTIQKNLHPTYSCTYDGCCVIDKITRNQCQLCRFKKCISVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPSPSAEEWELIHVVTEAHRSTNAQGSHWKQRRKFLLEDIGQSPMASMLDGDKVDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVDKIEKCQESYLLAFEHYINYRKHNIPHFWSKLLMKVADLRMIGAYHASRFLHMKVECPTELSPQEV
  
Inhibitor
Name:
BDBM50273881
Synonyms:
1-(1,1,1,-Trifluoromethyl)-3,4-dihydronaphthalene-2-carboxaldehyde guanylhydrazone | CHEMBL458495
Type:
Small organic molecule
Emp. Form.:
C13H13F3N4
Mol. Mass.:
282.2643
SMILES:
[#7]\[#6](-[#7])=[#7]\[#7]=[#6]-[#6]-1=[#6](-c2ccccc2-[#6]-[#6]-1)C(F)(F)F |w:5.5,t:6|
Structure:
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