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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50254576
Substrate
n/a
Meas. Tech.
ChEMBL_558763 (CHEMBL1019892)
IC50
1500±n/a nM
Citation
 Porter, J; Payne, A; de Candole, B; Ford, D; Hutchinson, B; Trevitt, G; Turner, J; Edwards, C; Watkins, C; Whitcombe, I; Davis, J; Stubberfield, C Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. Bioorg Med Chem Lett 19:230-3 (2008) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50254576
Synonyms:
CHEMBL464268 | {2-[3-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-5-methyl-pyrazol-1-yl]-phenyl}-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone
Type:
Small organic molecule
Emp. Form.:
C30H28N4O2
Mol. Mass.:
476.5689
SMILES:
Cc1cc(nn1-c1ccccc1C(=O)N1CCc2ccccc2C1)C(=O)N1CCc2ccccc2C1
Structure:
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