Reaction Details Report a problem with these data
Target
Melatonin receptor type 1A
Ligand
BDBM50240442
Substrate
n/a
Meas. Tech.
ChEMBL_517310 (CHEMBL1031363)
Ki
1290±n/a nM
Citation
 Zlotos, DP; Attia, MI; Julius, J; Sethi, S; Witt-Enderby, PA 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem 52:826-33 (2009) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50240442
Synonyms:
CHEMBL33185 | N-((1-(4-chlorobenzyl)-4-methoxy-1H-indol-2-yl)methyl)propionamide | N-[1-(4-Chloro-benzyl)-4-methoxy-1H-indol-2-ylmethyl]-propionamide
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O2
Mol. Mass.:
356.846
SMILES:
CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccc(Cl)cc1
Structure:
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