Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50240442
Substrate
n/a
Meas. Tech.
ChEMBL_517311 (CHEMBL1031364)
Ki
9±n/a nM
Citation
 Zlotos, DP; Attia, MI; Julius, J; Sethi, S; Witt-Enderby, PA 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem 52:826-33 (2009) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50240442
Synonyms:
CHEMBL33185 | N-((1-(4-chlorobenzyl)-4-methoxy-1H-indol-2-yl)methyl)propionamide | N-[1-(4-Chloro-benzyl)-4-methoxy-1H-indol-2-ylmethyl]-propionamide
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O2
Mol. Mass.:
356.846
SMILES:
CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccc(Cl)cc1
Structure:
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