Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50258100
Substrate
n/a
Meas. Tech.
ChEMBL_567024 (CHEMBL1029921)
IC50
200±n/a nM
Citation
 Sakamoto, T; Moriya, M; Haga, Y; Takahashi, T; Shibata, T; Okamoto, O; Nonoshita, K; Kitazawa, H; Hidaka, M; Gomori, A; Iwaasa, H; Ishihara, A; Kanatani, A; Fukami, T; Gao, YD; Macneil, DJ; Yang, L Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists. Bioorg Med Chem Lett 19:1564-8 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50258100
Synonyms:
CHEMBL492582 | cis-N-(biphenyl-4-yl)-1'-(methylsulfonyl)spiro[cyclohexane-1,3'-indoline]-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C27H28N2O3S
Mol. Mass.:
460.588
SMILES:
CS(=O)(=O)N1C[C@@]2(CC[C@@H](CC2)C(=O)Nc2ccc(cc2)-c2ccccc2)c2ccccc12 |r,wU:9.12,6.5,(-8.86,-28.6,;-8.08,-27.27,;-9.32,-26.36,;-6.83,-28.19,;-7.04,-26.13,;-5.5,-26.3,;-4.87,-24.88,;-3.54,-25.65,;-2.22,-24.89,;-2.21,-23.35,;-3.54,-22.58,;-4.88,-23.35,;-.87,-22.58,;-.87,-21.04,;.46,-23.36,;1.8,-22.59,;3.12,-23.37,;4.46,-22.6,;4.46,-21.06,;3.12,-20.28,;1.79,-21.05,;5.79,-20.29,;7.13,-21.06,;8.46,-20.29,;8.46,-18.75,;7.12,-17.98,;5.79,-18.75,;-6.02,-23.85,;-6.02,-22.3,;-7.36,-21.53,;-8.69,-22.3,;-8.69,-23.85,;-7.36,-24.62,)|
Structure:
Search PDB for entries with ligand similarity: