Reaction Details Report a problem with these data
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
Ligand
BDBM50259545
Substrate
n/a
Meas. Tech.
ChEMBL_500223 (CHEMBL980690)
IC50
700±n/a nM
Citation
Hopper, DW; Vera, MD; How, D; Sabatini, J; Xiang, JS; Ipek, M; Thomason, J; Hu, Y; Feyfant, E; Wang, Q; Georgiadis, KE; Reifenberg, E; Sheldon, RT; Keohan, CC; Majumdar, MK; Morris, EA; Skotnicki, J; Sum, PE Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors. Bioorg Med Chem Lett 19:2487-91 (2009) [PubMed] Article
More Info.:
Target
Name:
A disintegrin and metalloproteinase with thrombospondin motifs 4
Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) | ADAMTS4 | ATS4_HUMAN | Aggrecanase-1 | KIAA0688 | Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
Type:
Enzyme
Mol. Mass.:
90214.54
Organism:
Homo sapiens (Human)
Description:
O75173
Residue:
837
Sequence:
MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
Inhibitor
Name:
BDBM50259545
Synonyms:
(R)-3-methyl-2-(4'-(2-(3-methylbenzofuran-2-yl)acetoxy)biphenyl-4-ylsulfonamido)butanoic acid | CHEMBL467710
Type:
Small organic molecule
Emp. Form.:
C28H27NO7S
Mol. Mass.:
521.581
SMILES:
CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(OC(=O)Cc2oc3ccccc3c2C)cc1)C(O)=O |r|