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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50259496
Substrate
n/a
Meas. Tech.
ChEMBL_500250 (CHEMBL969585)
Ki
1300±n/a nM
Citation
 Marcaurelle, LA; Johannes, C; Yohannes, D; Tillotson, BP; Mann, D Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2. Bioorg Med Chem Lett 19:2500-3 (2009) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50259496
Synonyms:
(1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-thiazol-2-yl]-10-hydroxymethyl-6-oxo-7,12-diaza-tricyclo[7.2.1.0*2,7*]dodeca-2,4-diene-11-carboxylicacid (2-dimethylamino-ethyl)-amide | CHEMBL448237
Type:
Small organic molecule
Emp. Form.:
C31H32ClN5O3S
Mol. Mass.:
590.135
SMILES:
CN(C)CCNC(=O)[C@H]1[C@H](CO)[C@H]2Cn3c(cccc3=O)[C@@H]1N2c1nc(c(s1)-c1ccccc1)-c1ccc(Cl)cc1 |r|
Structure:
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