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Target
Beta-3 adrenergic receptor
Ligand
BDBM50259206
Substrate
n/a
Meas. Tech.
ChEMBL_498900 (CHEMBL972494)
EC50
390±n/a nM
Citation
 Maruyama, T; Onda, K; Hayakawa, M; Seki, N; Takahashi, T; Moritomo, H; Suzuki, T; Matsui, T; Takasu, T; Nagase, I; Ohta, M Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists. Bioorg Med Chem 17:3283-94 (2009) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50259206
Synonyms:
(S)-4'-(2-{[2-Hydroxy-3-phenoxypropyl]amino}ethyl)-2-(3-methyl-2-pyridyl)acetanilide | CHEMBL466924
Type:
Small organic molecule
Emp. Form.:
C25H29N3O3
Mol. Mass.:
419.5161
SMILES:
Cc1cccnc1CC(=O)Nc1ccc(CCNC[C@H](O)COc2ccccc2)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: