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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50259539
Substrate
n/a
Meas. Tech.
ChEMBL_499406 (CHEMBL1015858)
IC50
200±n/a nM
Citation
 Rich, JO; Budde, CL; McConeghey, LD; Cotterill, IC; Mozhaev, VV; Singh, SB; Goetz, MA; Zhao, A; Michels, PC; Khmelnitsky, YL Application of combinatorial biocatalysis for a unique ring expansion of dihydroxymethylzearalenone. Bioorg Med Chem Lett 19:3059-62 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50259539
Synonyms:
CHEMBL468117 | L-783279 | dihydroxymethylzearalenone
Type:
Small organic molecule
Emp. Form.:
C19H24O7
Mol. Mass.:
364.3897
SMILES:
COc1cc(O)c2c(c1)\C=C\C[C@@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O |r,t:10|
Structure:
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