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Target
Beta-secretase 1
Ligand
BDBM50258847
Substrate
n/a
Meas. Tech.
ChEMBL_500750 (CHEMBL970529)
pH
4.5±n/a
IC50
25000±n/a nM
Comments
extracted
Citation
 Stachel, SJ; Coburn, CA; Rush, D; Jones, KL; Zhu, H; Rajapakse, H; Graham, SL; Simon, A; Katharine Holloway, M; Allison, TJ; Munshi, SK; Espeseth, AS; Zuck, P; Colussi, D; Wolfe, A; Pietrak, BL; Lai, MT; Vacca, JP Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1. Bioorg Med Chem Lett 19:2977-80 (2009) [PubMed]  Article 
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM50258847
Synonyms:
4-(1-(4-methoxyphenyl)cyclopentyl)thiazol-2-amine | CHEMBL449357
Type:
Small organic molecule
Emp. Form.:
C15H18N2OS
Mol. Mass.:
274.381
SMILES:
COc1ccc(cc1)C1(CCCC1)c1csc(N)n1
Structure:
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