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Target
5-hydroxytryptamine receptor 3A/3B
Ligand
BDBM50280501
Substrate
n/a
Meas. Tech.
ChEMBL_3006 (CHEMBL619796)
Ki
41±n/a nM
Citation
 Langlois, M; Soulier, JL; Brémont, B; Shen, S; Rampillon, V; Giudice, A Derivatives of naphthalimide: new potent conformationally restricted antagonists of 5-HT3 receptors. Bioorg Med Chem Lett 2:691-694 (1992)    Article 
Target
Name:
5-hydroxytryptamine receptor 3A/3B
Synonyms:
Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 2974
Components:
This complex has 2 components.
Component 1
Name:
5-hydroxytryptamine receptor 3B
Synonyms:
5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor
Type:
PROTEIN
Mol. Mass.:
50328.78
Organism:
Rattus norvegicus
Description:
EBI_11885
Residue:
437
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTESPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVLGLYTVTLCSLWALWSRM
  
Component 2
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
RAT
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50280501
Synonyms:
2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-6-bromo-benzo[de]isoquinoline-1,3-dione | CHEMBL350423
Type:
Small organic molecule
Emp. Form.:
C19H17BrN2O2
Mol. Mass.:
385.254
SMILES:
Brc1ccc2C(=O)N(C3CN4CCC3CC4)C(=O)c3cccc1c23 |(4.93,-5.21,;6.47,-5.14,;7.18,-3.77,;8.7,-3.69,;9.52,-4.95,;11.09,-4.86,;11.76,-3.48,;11.92,-6.17,;13.47,-6.08,;14.31,-7.37,;15.84,-7.3,;16.54,-5.92,;15.67,-4.63,;14.15,-4.7,;14.55,-6.2,;15.56,-5.73,;11.23,-7.55,;12.09,-8.84,;9.69,-7.65,;8.98,-9,;7.44,-9.09,;6.61,-7.78,;7.32,-6.4,;8.84,-6.33,)|
Structure:
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