Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50281411
Substrate
n/a
Meas. Tech.
ChEBML_201272
Ki
4±n/a nM
Citation
 Schow, SR; Tam, SW Novel sigma receptor ligands 1. Bioorg Med Chem Lett 3:215-220 (1993)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50281411
Synonyms:
8-Benzyl-3-(4-fluoro-phenyl)-1-oxa-8-aza-spiro[4.5]decan-4-one; hydrochloride | 8-Benzyl-3-(4-fluoro-phenyl)-3-methyl-1-oxa-8-aza-spiro[4.5]decan-4-one; hydrochloride | CHEMBL543344
Type:
Small organic molecule
Emp. Form.:
C21H22FNO2
Mol. Mass.:
339.4033
SMILES:
Fc1ccc(cc1)C1COC2(CCN(Cc3ccccc3)CC2)C1=O
Structure:
Search PDB for entries with ligand similarity: