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Target
Peptidyl-prolyl cis-trans isomerase FKBP4
Ligand
BDBM50283387
Substrate
n/a
Meas. Tech.
ChEBML_154484
Ki
340000±n/a nM
Citation
 Luengo, JI; Konialian-Beck, A; Levy, MA; Brandt, M; Eggleston, DS; Holt, DA Synthesis and structure-activity relationships of macrocyclic FKBP ligands Bioorg Med Chem Lett 4:321-324 (1994)    Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:
FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:
PROTEIN
Mol. Mass.:
51793.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154482
Residue:
459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
  
Inhibitor
Name:
BDBM50283387
Synonyms:
(11E,13Z)-7,7-Dimethyl-1,3,4,7,8,16,17,18,19,20,21,23a-dodecahydro-2H,15H-9,22-dioxa-4a-aza-benzocyclohenicosene-5,6,10,23-tetraone | CHEMBL111188
Type:
Small organic molecule
Emp. Form.:
C24H35NO6
Mol. Mass.:
433.5378
SMILES:
CC1(C)COC(=O)\C=C\C=C/CCCCCCCOC(=O)C2CCCCN2C(=O)C1=O |c:9,t:7|
Structure:
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