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Target
Interstitial collagenase
Ligand
BDBM50283785
Substrate
n/a
Meas. Tech.
ChEBML_101742
IC50
30±n/a nM
Citation
 Hunter, DJ; Bird, J; Cassidy, F; De Mello, RC; Harper, GP; Karran, EH; Markwell, RE; Miles-Williams, AJ; Ward, RW Aminophosphonic acid containing inhibitors of human collagenase: modification of the P1 residue Bioorg Med Chem Lett 4:2833-2836 (1994)    Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50283785
Synonyms:
CHEMBL98233 | {(R)-3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-1-[(S)-3-methyl-1-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-butylamino]-propyl}-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C31H37N4O7P
Mol. Mass.:
608.6218
SMILES:
CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@@H](CCN1C(=O)c2cccc3cccc(C1=O)c23)P(O)(O)=O
Structure:
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