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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50284234
Substrate
n/a
Meas. Tech.
ChEBML_28168
IC50
50800±n/a nM
Citation
 Augelli-Szafran, CE; Roth, BD; Essenburg, A; Hamelehle, KL; Krause, BR; Stanfield, RL Imidazolidinones and pyrazolones as novel ACAT inhibitors: Chemistry and biological activity Bioorg Med Chem Lett 4:1095-1100 (1994)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50284234
Synonyms:
2-(2,6-Dimethyl-phenyl)-5-(2,2-diphenyl-ethyl)-2,4-dihydro-pyrazol-3-one | CHEMBL267305
Type:
Small organic molecule
Emp. Form.:
C25H24N2O
Mol. Mass.:
368.4709
SMILES:
Cc1cccc(C)c1-n1[nH]c(CC(c2ccccc2)c2ccccc2)cc1=O |(3.35,-1.54,;2.02,-2.31,;.68,-1.54,;-.64,-2.33,;-.64,-3.86,;.68,-4.63,;.68,-6.16,;2.02,-3.86,;3.36,-4.63,;3.52,-6.15,;5.02,-6.47,;5.42,-7.94,;6.89,-8.34,;7.98,-7.24,;7.57,-5.78,;8.65,-4.68,;10.14,-5.08,;10.55,-6.57,;9.45,-7.65,;7.29,-9.83,;6.2,-10.89,;6.61,-12.38,;8.08,-12.78,;9.17,-11.69,;8.77,-10.21,;5.79,-5.13,;4.75,-3.99,;5.08,-2.49,)|
Structure:
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