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Target
Type-1 angiotensin II receptor
Ligand
BDBM50284462
Substrate
n/a
Meas. Tech.
ChEMBL_36632 (CHEMBL652343)
IC50
20±n/a nM
Citation
 Walsh, TF; Fitch, KJ; Chang, RS; Faust, KA; Chen, TB; Kivlighn, SD; Zingaro, GJ; Lotti, VJ; Siegl, PK; Patchett, AA; Greenlee, WJ α-Phenoxyphenylacetic acid derived angiotensin II antagonists with low nanomolar AT1/AT2 receptor subtype affinity (Part II) Bioorg Med Chem Lett 5:1151-1154 (1995)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50284462
Synonyms:
CHEMBL278234 | [2-Allyl-4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenoxy]-phenyl-acetic acid
Type:
Small organic molecule
Emp. Form.:
C28H29N3O3
Mol. Mass.:
455.5482
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(O)=O)c2ccccc2)c(CC=C)c1
Structure:
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