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Target
Caspase-1
Ligand
BDBM50284724
Substrate
n/a
Meas. Tech.
ChEBML_90977
Ki
20000±n/a nM
Citation
 Mjalli, AM; Chapman, KT; Zhao, JJ; Thornberry, NA; Peterson, EP; MacCoss, M Inhibition of interleukin-1β converting enzyme by N-Acyl-aspartic acid ketones Bioorg Med Chem Lett 5:1405-1408 (1995)    Article 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM50284724
Synonyms:
3-Allyloxycarbonylamino-4-oxo-5-(3-phenyl-propionyloxy)-pentanoic acid | CHEMBL30415
Type:
Small organic molecule
Emp. Form.:
C18H21NO7
Mol. Mass.:
363.3618
SMILES:
OC(=O)C[C@H](NC(=O)OCC=C)C(=O)COC(=O)CCc1ccccc1
Structure:
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