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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50284852
Substrate
n/a
Meas. Tech.
ChEBML_54063
Ki
48±n/a nM
Citation
 Batt, DG; Copeland, RA; Dowling, RL; Gardner, TL; Jones, EA; Orwat, MJ; Pinto, DJ; Pitts, WJ; Magolda, RL; Jaffee, BD Immunosuppressive structure-activity relationships of Brequinar and related cinchoninic acid derivatives Bioorg Med Chem Lett 5:1549-1554 (1995)    Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50284852
Synonyms:
2-(2'-Fluoro-biphenyl-4-yl)-3-methyl-[1,7]naphthyridine-4-carboxylic acid | CHEMBL39971
Type:
Small organic molecule
Emp. Form.:
C22H15FN2O2
Mol. Mass.:
358.3651
SMILES:
Cc1c(nc2cnccc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F
Structure:
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